Rottlerin

Rottlerin, also known as mallotoxin, is a natural polyphenolic compound that is extracted from the Kamala tree (Mallotus philippensis). It is a potent and selective inhibitor of protein kinase C delta type (PKCδ). Rottlerin has been used in laboratory research to understand the role of PKCδ in cell biology.

History

Rottlerin was first isolated from the Kamala tree in the 19th century. The compound was named after the German botanist Johann Friedrich Rottler, who made significant contributions to the study of Indian botany.

Structure and Properties

Rottlerin is a polyphenolic compound with a complex structure that includes a chromone moiety and two phenol groups. It has a molecular weight of 394.4 g/mol. The compound is yellow and has a melting point of 238-240 °C.

Biological Activity

Rottlerin is a potent and selective inhibitor of PKCδ, a member of the protein kinase C family. PKCδ is involved in a variety of cellular processes, including cell proliferation, apoptosis, and differentiation. Rottlerin inhibits PKCδ by binding to the regulatory domain of the enzyme, preventing its activation.

In addition to its activity against PKCδ, Rottlerin has been shown to have other biological effects. These include anti-inflammatory, anti-cancer, and anti-diabetic activities. However, the mechanisms of these effects are not fully understood.

Use in Research

Rottlerin has been widely used in laboratory research to study the role of PKCδ in cell biology. It has been used to investigate the role of PKCδ in diseases such as cancer, diabetes, and neurodegenerative disorders.

Safety and Toxicity

Rottlerin is considered to be a safe compound for laboratory use. However, it should be handled with care as it can cause skin and eye irritation. Ingestion or inhalation of Rottlerin can be harmful.

See Also

• Protein kinase C
• Polyphenol
• Mallotus philippensis

References

Rottlerin Resources
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