Rozanolixizumab
Rozanolixizumab is a humanized monoclonal antibody designed for the treatment of autoimmune diseases. It targets the neonatal Fc receptor (FcRn), which plays a crucial role in the regulation of immunoglobulin G (IgG) antibodies. By inhibiting FcRn, rozanolixizumab reduces the levels of pathogenic IgG antibodies, thereby alleviating symptoms of autoimmune conditions.
Mechanism of Action[edit | edit source]
Rozanolixizumab works by binding to the neonatal Fc receptor (FcRn). FcRn is responsible for protecting IgG antibodies from lysosomal degradation, thus prolonging their half-life in the bloodstream. By inhibiting FcRn, rozanolixizumab accelerates the degradation of IgG antibodies, including those that are pathogenic. This reduction in IgG levels can help manage autoimmune diseases where IgG antibodies attack the body's own tissues.
Clinical Applications[edit | edit source]
Rozanolixizumab is being investigated for its potential in treating various autoimmune diseases, including:
Development and Approval[edit | edit source]
Rozanolixizumab is currently undergoing clinical trials to evaluate its safety and efficacy. The results of these trials will determine its potential approval by regulatory agencies such as the Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
Side Effects[edit | edit source]
As with any therapeutic antibody, rozanolixizumab may cause side effects. Common side effects observed in clinical trials include:
Related Pages[edit | edit source]
- Monoclonal antibody
- Autoimmune disease
- Neonatal Fc receptor
- Myasthenia gravis
- Immune thrombocytopenic purpura
- Chronic inflammatory demyelinating polyneuropathy
References[edit | edit source]
External Links[edit | edit source]
-
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD