RpoE

RpoE is a sigma factor that is part of the RNA polymerase complex in bacteria. It is also known as σ^E and is involved in the response to cell envelope stress in Escherichia coli and other bacteria.

Function

RpoE is a extracytoplasmic function sigma factor that is activated in response to stress conditions that affect the cell envelope, such as heat shock, oxidative stress, and misfolded proteins. Once activated, RpoE directs the RNA polymerase to transcribe genes that help the cell respond to these stress conditions.

Regulation

The activity of RpoE is regulated by a complex system that involves several other proteins. Under normal conditions, RpoE is sequestered by the anti-sigma factor RseA. When the cell envelope is stressed, RseA is degraded, freeing RpoE to interact with the RNA polymerase.

Role in disease

RpoE has been implicated in the virulence of several pathogenic bacteria, including Salmonella enterica and Pseudomonas aeruginosa. In these organisms, RpoE regulates the expression of genes that are important for survival in the host environment.

See also

• Sigma factor
• RNA polymerase
• Cell envelope
• Escherichia coli
• Salmonella enterica
• Pseudomonas aeruginosa

References

RpoE Resources
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