Ruzinurad
A medication used to treat gout
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Ruzinurad is a medication used in the treatment of gout, a form of arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint. It is specifically used to lower uric acid levels in the blood, which is a key factor in the development of gout.
Mechanism of Action[edit | edit source]
Ruzinurad works by inhibiting the function of a protein in the kidneys known as URAT1 (urate transporter 1). This protein is responsible for the reabsorption of uric acid from the urine back into the bloodstream. By inhibiting URAT1, ruzinurad increases the excretion of uric acid in the urine, thereby lowering the levels of uric acid in the blood.
Clinical Use[edit | edit source]
Ruzinurad is typically prescribed to patients who have not achieved adequate control of their uric acid levels with other medications, such as allopurinol or febuxostat. It is often used in combination with these medications to enhance their uric acid-lowering effects.
Administration[edit | edit source]
Ruzinurad is administered orally, usually once daily. The dosage may vary depending on the patient's response to the medication and their overall treatment plan for managing gout.
Side Effects[edit | edit source]
Common side effects of ruzinurad include headache, increased blood creatinine levels, and gastrointestinal disturbances such as nausea. Patients are advised to maintain adequate hydration to reduce the risk of kidney-related side effects.
Contraindications[edit | edit source]
Ruzinurad is contraindicated in patients with severe renal impairment, as the drug is primarily excreted by the kidneys. It is also not recommended for use in patients with a history of kidney stones or those who are hypersensitive to the drug.
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