Ruzinurad

Ruzinurad

Ruzinurad is a medication used primarily in the treatment of gout, a form of arthritis characterized by severe pain, redness, and tenderness in joints. It belongs to a class of drugs known as urate transporter inhibitors, which work by reducing the levels of uric acid in the blood.

Mechanism of Action

Ruzinurad functions by inhibiting the activity of the urate transporter 1 (URAT1) in the kidneys. This inhibition decreases the reabsorption of uric acid, thereby increasing its excretion through the urine. By lowering uric acid levels, ruzinurad helps to prevent the formation of urate crystals, which are responsible for the painful symptoms of gout.

Indications

Ruzinurad is indicated for the treatment of hyperuricemia in patients with gout who have not achieved target serum uric acid levels with xanthine oxidase inhibitors alone. It is often used in combination with other medications such as allopurinol or febuxostat.

Dosage and Administration

The dosage of ruzinurad is typically individualized based on the patient's condition and response to treatment. It is usually administered orally, and the specific dosage regimen should be determined by a healthcare provider.

Side Effects

Common side effects of ruzinurad may include:

• Headache
• Nausea
• Diarrhea
• Dizziness

Serious side effects, although rare, can include:

• Kidney stones
• Acute renal failure
• Severe allergic reactions

Contraindications

Ruzinurad is contraindicated in patients with:

• Severe renal impairment
• Hypersensitivity to the drug or its components
• Tumor lysis syndrome

Drug Interactions

Ruzinurad may interact with other medications, including:

• Aspirin
• Diuretics
• Other drugs that affect kidney function

Related Pages

• Gout
• Uric acid
• Allopurinol
• Febuxostat
• Hyperuricemia
• Urate transporter 1

See Also

• Arthritis
• Renal function
• Xanthine oxidase inhibitors

External Links

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