S-444,823

From WikiMD's Wellnesspedia

S-444,823 is a pharmaceutical drug developed by Shionogi, a Japanese pharmaceutical company. It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV infections.

History[edit | edit source]

S-444,823 was first synthesized by Shionogi in the early 2000s as part of their ongoing research into effective treatments for HIV. The drug was designed to inhibit the reverse transcriptase enzyme, a key component in the replication of the HIV virus.

Mechanism of Action[edit | edit source]

As an NNRTI, S-444,823 works by binding to the reverse transcriptase enzyme, preventing it from converting the virus's RNA into DNA. This stops the virus from integrating its genetic material into the host cell's DNA, effectively halting the replication process.

Clinical Trials[edit | edit source]

S-444,823 has undergone several clinical trials to determine its safety and efficacy. Early trials showed promising results, with the drug demonstrating a high level of potency against HIV. Further trials are ongoing to determine the optimal dosage and to assess the drug's long-term effects.

Side Effects[edit | edit source]

As with all medications, S-444,823 can cause side effects. These can include nausea, vomiting, diarrhea, and rash. In rare cases, the drug can cause serious side effects such as liver damage and severe skin reactions.

Future Research[edit | edit source]

Research into S-444,823 is ongoing, with scientists continuing to explore its potential uses. In addition to its current use in treating HIV, the drug may also have potential applications in the treatment of other viral diseases.

See Also[edit | edit source]

Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.


Contributors: Prab R. Tumpati, MD