SAGE-718
SAGE-718 is an experimental drug developed by Sage Therapeutics, a biopharmaceutical company based in Cambridge, Massachusetts. It is currently under investigation for its potential use in the treatment of various central nervous system (CNS) disorders, including Huntington's disease, Parkinson's disease, and Alzheimer's disease.
Mechanism of Action[edit | edit source]
SAGE-718 is a positive allosteric modulator of the NMDA receptor, a type of ionotropic glutamate receptor in the brain. By enhancing the function of the NMDA receptor, SAGE-718 may help to improve cognitive function and reduce symptoms in patients with CNS disorders.
Clinical Trials[edit | edit source]
As of 2021, SAGE-718 is in Phase 2 clinical trials for the treatment of cognitive impairment associated with Huntington's disease. Preliminary results from these trials have shown promise, with patients demonstrating improved cognitive function after treatment with SAGE-718.
Potential Applications[edit | edit source]
In addition to its potential use in treating Huntington's disease, SAGE-718 is also being investigated for its potential use in treating other CNS disorders, including Parkinson's disease and Alzheimer's disease. Further research is needed to determine the efficacy and safety of SAGE-718 in these patient populations.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
