SB-205384

SB-205384

SB-205384 is a pharmacological compound that is primarily used in scientific research. It is a positive allosteric modulator of the GABAA receptor, a type of protein that responds to the neurotransmitter gamma-aminobutyric acid (GABA).

Pharmacology

SB-205384 is known to enhance the action of GABA at the GABAA receptor, but it does not bind to the same site on the receptor as GABA itself. Instead, it binds to a distinct site that is referred to as an allosteric site. When SB-205384 binds to this site, it changes the shape of the GABAA receptor in a way that increases the receptor's response to GABA. This is why SB-205384 is described as a positive allosteric modulator.

Research Uses

In scientific research, SB-205384 is often used to study the function of the GABAA receptor and the effects of enhancing GABAergic signaling. For example, it has been used in studies investigating the role of GABA in anxiety, sleep disorders, and epilepsy.

Chemistry

SB-205384 is a synthetic compound. Its chemical structure includes a pyrazoloquinolinone core, which is thought to be important for its activity at the GABAA receptor.

Safety and Side Effects

As a research compound, SB-205384 is not intended for human consumption, and its safety and side effects in humans have not been thoroughly studied. However, in animal studies, it has been found to cause sedation and muscle relaxation, which are common effects of drugs that enhance GABAergic signaling.

See Also

• Allosteric modulator
• GABAA receptor
• Gamma-aminobutyric acid