SCG2
SCG2 or Secretogranin II is a protein that in humans is encoded by the SCG2 gene. It is a member of the granin family of neuroendocrine secretory proteins, which are precursors for various bioactive peptides.
Function[edit | edit source]
SCG2 is a chromogranin and secretogranin that are located in secretory vesicles of neurons and endocrine cells. This protein is a precursor for multiple peptides including secretoneurin, which has been implicated in the regulation of neurotransmitter release and inflammatory processes.
Clinical significance[edit | edit source]
Alterations in the SCG2 gene have been associated with susceptibility to schizophrenia. Moreover, SCG2 has been identified as a potential biomarker for neuroendocrine tumors.
Structure[edit | edit source]
The SCG2 gene is located on the short arm of chromosome 2 (2q35-q36). It spans about 15 kb and consists of 7 exons. The SCG2 protein is a 617-amino acid polypeptide.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
