SCG2

SCG2 or Secretogranin II is a protein that in humans is encoded by the SCG2 gene. It is a member of the granin family of neuroendocrine secretory proteins, which are precursors for various bioactive peptides.

Function

SCG2 is a chromogranin and secretogranin that are located in secretory vesicles of neurons and endocrine cells. This protein is a precursor for multiple peptides including secretoneurin, which has been implicated in the regulation of neurotransmitter release and inflammatory processes.

Clinical significance

Alterations in the SCG2 gene have been associated with susceptibility to schizophrenia. Moreover, SCG2 has been identified as a potential biomarker for neuroendocrine tumors.

Structure

The SCG2 gene is located on the short arm of chromosome 2 (2q35-q36). It spans about 15 kb and consists of 7 exons. The SCG2 protein is a 617-amino acid polypeptide.

See also

• Chromogranin
• Secretogranin
• Neuroendocrine tumor
• Schizophrenia

References

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