SCH-79797

SCH-79797 is a potent and selective antibiotic and anticoagulant compound. It is a small molecule that has been shown to have both antibacterial and antithrombotic properties.

Mechanism of Action

SCH-79797 works by inhibiting the bacterial quinolone resistance protein, NorA, which is a major facilitator superfamily (MFS) drug efflux pump. This inhibition increases the susceptibility of bacteria to various antibiotics. In addition, SCH-79797 also inhibits thrombin, a key enzyme in the coagulation cascade, thereby preventing blood clot formation.

Pharmacology

SCH-79797 is a dual-action compound, acting as both an antibiotic and an anticoagulant. As an antibiotic, it is effective against both Gram-positive and Gram-negative bacteria, including strains that are resistant to other antibiotics. As an anticoagulant, it is effective in preventing thrombosis without causing bleeding, a common side effect of many anticoagulants.

Clinical Use

While SCH-79797 has shown promise in preclinical studies, it is not yet approved for use in humans. Further research is needed to determine its safety and efficacy in clinical settings.

Potential Applications

Given its dual-action properties, SCH-79797 has potential applications in the treatment of infectious diseases and thrombotic disorders. It could be particularly useful in situations where both infection and thrombosis are present, such as in sepsis or endocarditis.

See Also

• Antibiotics
• Anticoagulants
• Thrombin
• Quinolone