SIRT1
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| Identifiers | |
|---|---|
| EC number | 3.5.1.98 |
| CAS number | 60476-59-3 |
| Alt. names | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
SIRT1, also known as sirtuin 1, is a protein that in humans is encoded by the SIRT1 gene. It is a member of the sirtuin family of proteins, which are characterized by their unique enzyme activity known as deacetylase. This activity is dependent on nicotinamide adenine dinucleotide (NAD+), making SIRT1 part of a crucial group of enzymes involved in cellular regulation mechanisms, including aging, inflammation, and stress resistance.
Function[edit | edit source]
SIRT1 is involved in various cellular processes. It deacetylates histones and several other proteins that regulate gene expression, DNA repair, and metabolism. By removing acetyl groups from specific proteins, SIRT1 can influence the activity of these proteins, thereby regulating important cellular functions such as apoptosis (programmed cell death) and lipid metabolism.
Clinical Significance[edit | edit source]
SIRT1 has been implicated in the pathophysiology of several diseases, including diabetes, neurodegenerative diseases such as Alzheimer's disease, and cardiovascular diseases. Its role in extending cell life and preventing aging has made it a target for potential therapeutic interventions. Drugs that can enhance the activity of SIRT1 are being studied for their ability to treat age-related diseases and extend healthy lifespan.
Research[edit | edit source]
Research on SIRT1 has focused on its potential benefits in combating various age-related conditions. Studies have shown that increasing SIRT1 activity can mimic the effects of caloric restriction, a known mechanism for extending lifespan in various organisms. This has led to the development of SIRT1-activating compounds, which are being investigated for their therapeutic potential.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
