SIRT1
| Identifiers | |
|---|---|
| EC number | 3.5.1.98 |
| CAS number | 60476-59-3 |
| Alt. names | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
SIRT1, also known as sirtuin 1, is a protein that in humans is encoded by the SIRT1 gene. It is a member of the sirtuin family of proteins, which are characterized by their unique enzyme activity known as deacetylase. This activity is dependent on nicotinamide adenine dinucleotide (NAD+), making SIRT1 part of a crucial group of enzymes involved in cellular regulation mechanisms, including aging, inflammation, and stress resistance.
Function[edit | edit source]
SIRT1 is involved in various cellular processes. It deacetylates histones and several other proteins that regulate gene expression, DNA repair, and metabolism. By removing acetyl groups from specific proteins, SIRT1 can influence the activity of these proteins, thereby regulating important cellular functions such as apoptosis (programmed cell death) and lipid metabolism.
Clinical Significance[edit | edit source]
SIRT1 has been implicated in the pathophysiology of several diseases, including diabetes, neurodegenerative diseases such as Alzheimer's disease, and cardiovascular diseases. Its role in extending cell life and preventing aging has made it a target for potential therapeutic interventions. Drugs that can enhance the activity of SIRT1 are being studied for their ability to treat age-related diseases and extend healthy lifespan.
Research[edit | edit source]
Research on SIRT1 has focused on its potential benefits in combating various age-related conditions. Studies have shown that increasing SIRT1 activity can mimic the effects of caloric restriction, a known mechanism for extending lifespan in various organisms. This has led to the development of SIRT1-activating compounds, which are being investigated for their therapeutic potential.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
