SL651498

SL651498 is a anxiolytic drug with a novel chemical structure, which is used in the treatment of anxiety disorders. It has similar effects to benzodiazepine drugs, but with a different mechanism of action.

Chemistry

SL651498 is a GABA_A receptor positive allosteric modulator. This means it enhances the effect of the neurotransmitter GABA on the GABA_A receptor, which results in increased inhibitory effects of GABA on neuronal excitability. This is the same mechanism of action as benzodiazepines, but SL651498 is not structurally related to the benzodiazepine class of drugs.

Pharmacology

SL651498 has been shown to have anxiolytic, anticonvulsant, and sedative effects in animal studies. It has a rapid onset of action, and does not produce tolerance or physical dependence with chronic use. This makes it a potential alternative to benzodiazepines for the treatment of anxiety disorders.

Clinical use

SL651498 is currently in clinical trials for the treatment of anxiety disorders. Preliminary results suggest it may be effective and well-tolerated, but further research is needed to confirm these findings.

See also

• Anxiety disorder
• GABA_A receptor
• Benzodiazepine

References

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