SLC11A1

SLC11A1 (Solute Carrier Family 11 Member 1) is a protein that in humans is encoded by the SLC11A1 gene. It is also known as natural resistance-associated macrophage protein 1 (NRAMP 1). This protein is found in the lysosomal membrane of macrophages and plays a crucial role in the regulation of divalent metal ions like iron and zinc.

Function

The SLC11A1 gene provides instructions for making a protein that is critical for the normal function of macrophages, which are a type of white blood cell that digests foreign bacteria and other substances. This protein helps control the level of certain ions within macrophages, which is necessary for the cells to kill bacteria effectively.

Clinical significance

Mutations in the SLC11A1 gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis.

See also

• Solute carrier family
• Macrophage
• Lysosome

External links

• SLC11A1 at NCBI
• SLC11A1 at Genetics Home Reference

SLC11A1 Resources
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