SR-16435

SR-16435 is a chemical compound that is often used in scientific research. It is a member of the benzodiazepine class of drugs, which are known for their sedative and anxiolytic effects. However, unlike most benzodiazepines, SR-16435 is not used clinically due to its high potency and potential for abuse.

Chemistry

SR-16435 is a benzodiazepine, a class of drugs that are typically characterized by a core structure of a benzene ring fused to a diazepine ring. The chemical structure of SR-16435 is unique among benzodiazepines due to the presence of a fluorine atom at the 7th position of the diazepine ring, which is believed to contribute to its high potency.

Pharmacology

Like other benzodiazepines, SR-16435 acts as a positive allosteric modulator of the GABA_A receptor, the major inhibitory neurotransmitter receptor in the brain. This means that it enhances the effect of GABA at this receptor, leading to increased inhibitory effects on neuronal activity. This is believed to be the mechanism underlying the sedative and anxiolytic effects of benzodiazepines.

Research Use

Due to its high potency, SR-16435 is primarily used in scientific research rather than clinical practice. It is often used in studies investigating the pharmacology of benzodiazepines and the GABA_A receptor. For example, it has been used in studies investigating the role of the GABA_A receptor in anxiety and sleep disorders.

Potential for Abuse

Like other benzodiazepines, SR-16435 has a high potential for abuse. This is due to its ability to produce feelings of relaxation and euphoria, which can lead to psychological dependence. For this reason, it is classified as a Schedule IV controlled substance in the United States.

See Also

• Benzodiazepine
• GABA_A receptor
• Schedule IV controlled substance