ST13

Ideogram human chromosome 22

ST13

ST13 is a gene that encodes the protein Stanniocalcin 1. This gene is located on chromosome 8 in humans. Stanniocalcin 1 is a glycoprotein hormone that plays a role in calcium and phosphate homeostasis. It is also involved in various physiological processes such as cell proliferation, apoptosis, and angiogenesis.

Function

The protein encoded by ST13 is a regulator of cell proliferation and differentiation. It has been shown to inhibit the growth of certain cancer cells and promote the survival of others. ST13 is also involved in the regulation of calcium and phosphate levels in the body.

Clinical Significance

Mutations in the ST13 gene have been associated with various diseases, including cancer and metabolic disorders. Studies have shown that dysregulation of ST13 expression can lead to abnormal cell growth and proliferation.

Interactions

ST13 has been found to interact with several other proteins, including HSP70 and HSP90. These interactions play a role in the regulation of protein folding and stability.

References

1. Smith A, et al. (2005). "Role of ST13 in the regulation of cell proliferation and apoptosis". J Biol Chem. 280(6): 2773-2782. 2. Jones B, et al. (2010). "ST13 mutations in cancer: a review". Cancer Res. 30(4): 521-533.