Saclofen

Saclofen is a pharmacological agent that is used in scientific research. It acts as an antagonist at the GABAB receptor.^[1]

Pharmacology[edit | edit source]

Saclofen is a competitive antagonist for the GABAB receptor. This means it binds to the same site on the receptor as the endogenous ligand, GABA. However, unlike GABA, saclofen does not activate the receptor. Instead, it prevents GABA from binding, thereby inhibiting its effects.^[2]

Uses[edit | edit source]

Saclofen is primarily used in scientific research. It is often used to study the function of the GABAB receptor and the role of this receptor in various physiological and pathological processes.^[3]

References[edit | edit source]

↑ , GABAA and GABAB receptor site distribution in the rat central nervous system, Neuroscience, Vol. 20(Issue: 2), pp. 365–83, DOI: 10.1016/0306-4522(87)90098-4, PMID: 2884340,
↑ , (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor, Nature, Vol. 283(Issue: 5742), pp. 92–4, DOI: 10.1038/283092a0, PMID: 6100726,
↑ , International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function, Pharmacological Reviews, Vol. 54(Issue: 2), pp. 247–64, DOI: 10.1124/pr.54.2.247, PMID: 12037140,

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Saclofen gallery[edit | edit source]

Saclofen chemical structure

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[1] , GABAA and GABAB receptor site distribution in the rat central nervous system, Neuroscience, Vol. 20(Issue: 2), pp. 365–83, DOI: 10.1016/0306-4522(87)90098-4, PMID: 2884340,

[2] , (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor, Nature, Vol. 283(Issue: 5742), pp. 92–4, DOI: 10.1038/283092a0, PMID: 6100726,

[3] , International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function, Pharmacological Reviews, Vol. 54(Issue: 2), pp. 247–64, DOI: 10.1124/pr.54.2.247, PMID: 12037140,

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