Salsolinol
Salsolinol is a tetrahydroisoquinoline alkaloid that is formed in the human body from dopamine and acetaldehyde. It is a neurotoxin and has been suggested to have a possible role in alcoholism.
Chemistry[edit | edit source]
Salsolinol is a tetrahydroisoquinoline, a type of alkaloid. It is formed in the body from the condensation of dopamine and acetaldehyde. This reaction is catalyzed by the enzyme Catechol-O-methyl transferase (COMT).
Pharmacology[edit | edit source]
Salsolinol has been found to have neurotoxic effects. It is thought to cause damage to the dopaminergic neurons in the brain, which may contribute to the development of Parkinson's disease.
In addition to its neurotoxic effects, salsolinol has also been found to have rewarding effects. It has been suggested that it may contribute to the reinforcing effects of alcohol, and thus play a role in the development of alcoholism.
Role in Alcoholism[edit | edit source]
The role of salsolinol in alcoholism is not fully understood. Some studies have found that the levels of salsolinol in the body are increased after alcohol consumption, and that these levels are higher in individuals with alcoholism compared to those without. However, other studies have not found a clear link between salsolinol levels and alcohol consumption or alcoholism.
See also[edit | edit source]
References[edit | edit source]
| Salsolinol Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
