Sarcosine

Sarcosine, also known as N-methylglycine, is an intermediate and byproduct in glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. Sarcosine is a natural amino acid found in muscles and other body tissues. In the laboratory, it may be synthesized from chloroacetic acid and methylamine. Sarcosine is found naturally as an intermediate in the metabolism of choline to glycine.

Sarcosine is sweet to the taste and dissolves in water. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications.

Health and medical use

Sarcosine is reported to be a natural antidepressant and may act as a mood stabilizer. Some research suggests that sarcosine may be helpful in addressing symptoms of schizophrenia and depression.

Biochemical role

Sarcosine is involved in the metabolism of methionine and folate. It is also a component of creatine, a compound that provides energy to muscles and nerve cells.

See also

• Glycine
• Methylamine
• Chloroacetic acid
• Schizophrenia
• Depression

Sarcosine Resources
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