Schaffer collateral

Schaffer Collateral is a type of axon that originates from the CA3 region of the hippocampus and terminates in the CA1 region. It is named after the neurologist Heinrich Schaffer who first described it. The Schaffer Collateral is an important part of the trisynaptic circuit, which is the main circuitry of the hippocampus.

Function

The Schaffer Collateral plays a crucial role in the functioning of the hippocampus. It is involved in the transmission of electrical impulses from the CA3 region to the CA1 region. This transmission is essential for the processing of memory and learning.

Structure

The Schaffer Collateral is a type of excitatory synapse. It originates from the pyramidal cells in the CA3 region and terminates in the CA1 region. The axons of the Schaffer Collateral form synapses with the dendrites of the pyramidal cells in the CA1 region.

Clinical Significance

Damage to the Schaffer Collateral can lead to impairments in memory and learning. It has been implicated in various neurological disorders, including Alzheimer's disease and epilepsy.

Research

Research on the Schaffer Collateral has provided valuable insights into the functioning of the hippocampus and the mechanisms of memory and learning. It has also led to the development of new therapeutic strategies for neurological disorders.

See Also

• Hippocampus
• Axon
• Synapse
• Neuron
• Neurology

References

Schaffer collateral Resources
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