Sclerotome
Sclerotome is a part of the somite in a developing embryo. It is the medial part of the somite and it gives rise to the vertebrae and ribs. The sclerotome is formed from the ventromedial part of the somite and it is induced by signals from the notochord.
Development[edit | edit source]
The notochord releases a sonic hedgehog (SHH) protein that induces the ventromedial cells of the somite to become the sclerotome. The cells of the sclerotome undergo a process called epithelial to mesenchymal transition where they lose their epithelial characteristics and gain mesenchymal characteristics. This allows them to migrate and surround the notochord and neural tube to form the vertebral body and intervertebral discs.
Function[edit | edit source]
The sclerotome forms the axial skeleton which includes the vertebrae and the ribs. The vertebrae are formed from the sclerotome cells that surround the notochord and neural tube. The ribs are formed from the lateral part of the sclerotome that migrates towards the surface ectoderm.
Clinical significance[edit | edit source]
Defects in the formation of the sclerotome can lead to skeletal abnormalities such as scoliosis, spina bifida, and vertebral segmentation defects.
See also[edit | edit source]
References[edit | edit source]
| Sclerotome Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
