Securinine
Securinine is a plant alkaloid derived from the roots of Securinega suffruticosa. It is a GABAA receptor antagonist and has been used in the treatment of neurological disorders. It has also been studied for its potential use in the treatment of cancer.
History[edit | edit source]
Securinine was first isolated in 1956 from the roots of Securinega suffruticosa. It was initially used in traditional Chinese medicine for the treatment of neurological disorders such as paralysis and epilepsy. In recent years, it has been studied for its potential use in the treatment of cancer.
Pharmacology[edit | edit source]
Securinine is a GABAA receptor antagonist. It works by blocking the action of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits the activity of nerve cells. By blocking the action of GABA, securinine can increase the activity of nerve cells.
Medical uses[edit | edit source]
Securinine has been used in the treatment of neurological disorders such as paralysis and epilepsy. It has also been studied for its potential use in the treatment of cancer. However, more research is needed to confirm its effectiveness and safety in these applications.
Side effects[edit | edit source]
The side effects of securinine are not well-studied. However, as a GABAA receptor antagonist, it may cause side effects such as anxiety, restlessness, and insomnia.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
