Sematilide

Sematilide

Sematilide is a Class III antiarrhythmic agent that is used in the treatment of cardiac arrhythmias. It is a non-cardioselective compound with significant Class III antiarrhythmic properties, similar to amiodarone.

Pharmacology

Sematilide works by blocking potassium channels, which prolongs the duration of the action potential and refractory period in myocardial tissue. This action can suppress abnormal electrical activity in the heart and restore normal heart rhythm.

Clinical Use

Sematilide is used in the treatment of various types of cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. It is particularly effective in treating arrhythmias that are resistant to other antiarrhythmic drugs.

Side Effects

Like other Class III antiarrhythmic agents, Sematilide can cause a variety of side effects. These can include nausea, vomiting, dizziness, and fatigue. In rare cases, it can also cause more serious side effects such as proarrhythmia, a condition where the drug can cause new or worsening arrhythmias.

Contraindications

Sematilide is contraindicated in patients with severe heart failure, hypokalemia, or hypomagnesemia. It should also be used with caution in patients with a history of proarrhythmia or other serious heart conditions.

Drug Interactions

Sematilide can interact with a number of other drugs, including other antiarrhythmics, beta blockers, and certain antidepressants. These interactions can increase the risk of side effects and should be monitored closely by a healthcare provider.

See Also

• Class III antiarrhythmic agent
• Cardiac arrhythmia
• Atrial fibrillation
• Ventricular tachycardia

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