Septum intermedium

Septum intermedium is a structure in the developing heart during embryonic development. It is a crucial component in the formation of the heart's four chambers, and any abnormalities in its development can lead to congenital heart defects.

Development

The septum intermedium forms during the fifth week of embryonic development. It arises from the fusion of the endocardial cushions, which are swellings of the endocardium, the innermost layer of the heart. These cushions grow towards each other and eventually fuse to form the septum intermedium.

The septum intermedium, along with the septum primum and septum secundum, contributes to the formation of the atrial septum, which separates the left and right atria of the heart. The septum intermedium specifically contributes to the formation of the atrioventricular septum, which separates the atria from the ventricles.

Clinical significance

Abnormalities in the development of the septum intermedium can lead to congenital heart defects such as atrioventricular septal defect (AVSD), also known as endocardial cushion defect. This condition is characterized by a hole in the center of the heart, where the septum intermedium should be, and often requires surgical intervention.

See also

• Heart development
• Congenital heart defect
• Endocardial cushion defect