Serotonin antagonist and reuptake inhibitor

Serotonin antagonist and reuptake inhibitors (SARIs) are a type of drug used primarily in the treatment of depression and anxiety disorders. The efficacy of SARIs as a treatment option is due to their ability to inhibit the reuptake of serotonin, and to antagonize (or block) the serotonin receptors in the brain. This dual action can help to enhance and regulate mood.

Mechanism of Action

SARIs work by inhibiting the reuptake of serotonin in the brain. Serotonin is a neurotransmitter, a type of chemical that helps transmit signals in the brain. By preventing the reuptake of serotonin, SARIs increase the amount of serotonin that is available in the brain. This can help to improve mood and reduce feelings of anxiety.

In addition to inhibiting the reuptake of serotonin, SARIs also act as antagonists at the serotonin receptors. This means that they block the action of serotonin at these receptors, which can help to further regulate mood.

Uses

SARIs are used primarily in the treatment of depression and anxiety disorders. They may also be used to treat other conditions, such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and certain types of chronic pain.

Side Effects

Like all drugs, SARIs can have side effects. These may include nausea, dizziness, sleepiness, dry mouth, and sexual dysfunction. In rare cases, SARIs can cause a serious condition called serotonin syndrome, which is characterized by high levels of serotonin in the brain.

Examples

Examples of SARIs include trazodone and nefazodone. These drugs are often used when other treatments for depression or anxiety have not been effective.

See Also

• Selective serotonin reuptake inhibitors (SSRIs)
• Serotonin and norepinephrine reuptake inhibitors (SNRIs)
• Tricyclic antidepressants (TCAs)

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