Serotonin antagonists and reuptake inhibitors

Serotonin Antagonists and Reuptake Inhibitors (SARIs) are a class of drugs used primarily in the treatment of depression and anxiety disorders. The name 'Serotonin Antagonists and Reuptake Inhibitors' is an umbrella term for any drugs that inhibit the reuptake of serotonin, and also antagonize (block) its receptors.

Mechanism of Action

SARIs work by inhibiting the reuptake of serotonin, a neurotransmitter that is involved in the regulation of mood, appetite, and sleep. By blocking the reuptake of serotonin, these drugs increase the amount of serotonin available in the brain. This can help to alleviate symptoms of depression and anxiety.

In addition to inhibiting the reuptake of serotonin, SARIs also act as antagonists at certain serotonin receptors. This means that they block these receptors, preventing serotonin from binding to them. This can further increase the amount of serotonin available in the brain.

Uses

SARIs are primarily used in the treatment of depression and anxiety disorders. They may also be used to treat other conditions, such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and certain types of chronic pain.

Side Effects

Like all drugs, SARIs can have side effects. These may include nausea, dizziness, sleepiness, dry mouth, and sexual dysfunction. In rare cases, they can also cause a serious condition known as serotonin syndrome, which is characterized by symptoms such as agitation, hallucinations, rapid heartbeat, and high body temperature.

Examples

Examples of SARIs include trazodone, nefazodone, and vilazodone. These drugs are all used in the treatment of depression, and have similar mechanisms of action.

See Also

• Selective serotonin reuptake inhibitors (SSRIs)
• Serotonin and norepinephrine reuptake inhibitors (SNRIs)
• Tricyclic antidepressants (TCAs)
• Monoamine oxidase inhibitors (MAOIs)

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