Sarolaner
(Redirected from Simparica)
Sarolaner is a parasiticide used in veterinary medicine to treat and prevent infestations of fleas and ticks in dogs. It belongs to the isoxazoline class of compounds, which are known for their efficacy against a wide range of ectoparasites.
Mechanism of Action[edit | edit source]
Sarolaner works by inhibiting the function of gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels in the nervous system of parasites. This leads to uncontrolled neuromuscular activity, resulting in the death of the parasites. The compound is highly selective for the GABA and glutamate receptors in insects and acarines, making it safe for use in dogs.
Indications[edit | edit source]
Sarolaner is indicated for the treatment and prevention of:
- Flea infestations (Ctenocephalides felis)
- Tick infestations, including Ixodes scapularis, Amblyomma americanum, Dermacentor variabilis, and Rhipicephalus sanguineus
Administration[edit | edit source]
Sarolaner is typically administered orally in the form of a chewable tablet. The dosage is based on the dog's weight, and it is usually given once a month. It is important to follow the veterinarian's instructions for dosage and administration to ensure the effectiveness of the treatment.
Safety and Side Effects[edit | edit source]
Sarolaner is generally well-tolerated in dogs. However, some potential side effects may include:
In rare cases, more severe reactions such as seizures may occur, particularly in dogs with a history of neurological disorders. It is important to consult a veterinarian if any adverse reactions are observed.
Contraindications[edit | edit source]
Sarolaner should not be used in dogs with known hypersensitivity to the active ingredient or any of the excipients. It is also not recommended for use in puppies less than 8 weeks of age or weighing less than 1.3 kg.
Combination Products[edit | edit source]
Sarolaner is sometimes combined with other active ingredients to broaden its spectrum of activity. For example, it is available in combination with moxidectin and pyrantel in a product used to treat and prevent multiple parasitic infections, including heartworm disease and intestinal worms.
See Also[edit | edit source]
References[edit | edit source]
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