SIVA1

SIVA1 is a gene that encodes a protein which plays a significant role in apoptosis. This protein is known to be a direct target of the tumor suppressor p53 and is highly likely to contribute to the execution of p53-dependent apoptosis.

Function

The SIVA1 gene encodes a protein that is a known apoptosis-inducing factor. It is characterized by its ability to bind various apoptosis-related proteins, including caspase-8, Fas, and Fas ligand. The protein encoded by SIVA1 is also known to interact with the death domain of Fas, which is a cell surface receptor involved in apoptosis.

Clinical significance

Mutations in the SIVA1 gene have been associated with various types of cancer, including breast cancer, lung cancer, and colorectal cancer. The protein encoded by this gene is thought to play a role in the development and progression of these cancers.

Research

Research into the SIVA1 gene and its encoded protein is ongoing, with a focus on understanding its role in apoptosis and its potential as a target for cancer therapy.

See also

• Apoptosis
• Caspase-8
• Fas
• Fas ligand
• Breast cancer
• Lung cancer
• Colorectal cancer

External links

• NCBI Gene
• UniProt

SIVA1 Resources
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