Small-blue-round-cell tumor

Small blue round cell tumor (SBRCT) is a term used to describe a group of neoplasms characterized by small, round, relatively undifferentiated cells. They are observed in microscopic examination and are most commonly found in the pediatric population. The group includes Ewing's sarcoma, neuroblastoma, rhabdomyosarcoma, Wilms' tumor, desmoplastic small round cell tumor, and synovial sarcoma.

Classification

SBRCTs are classified into the following types:

• Ewing's sarcoma: A rare disease in which cancer cells are found in the bone or in soft tissue.
• Neuroblastoma: A type of cancer that forms in certain types of nerve tissue.
• Rhabdomyosarcoma: A type of cancer that forms in skeletal muscle cells.
• Wilms' tumor: A type of cancer that starts in the kidneys.
• Desmoplastic small round cell tumor: A rare, aggressive form of cancer that primarily affects males.
• Synovial sarcoma: A type of cancer that occurs primarily in the extremities of the arms or legs.

Diagnosis

The diagnosis of SBRCTs is challenging due to their similar histological features. It often requires the use of immunohistochemistry and other advanced techniques such as fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR).

Treatment

Treatment of SBRCTs typically involves a combination of surgery, radiation therapy, and chemotherapy. The choice of treatment depends on the type of SBRCT, its location, and the patient's overall health.

Prognosis

The prognosis of SBRCTs varies widely depending on the type of tumor, its location, and the patient's overall health. Some types of SBRCTs, such as Wilms' tumor and neuroblastoma, have relatively good prognoses with appropriate treatment, while others, such as desmoplastic small round cell tumor, have a poorer prognosis.

See also

• Cancer
• Pediatric oncology
• Pathology

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