Small nucleolar rna host gene 1

Small Nucleolar RNA Host Gene 1 (SNHG1) is a gene that in humans is encoded by the SNHG1 gene. It is a long non-coding RNA gene, and is also known as U22HG (U22 Host Gene).

Function

Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs which are associated with methylation, and the H/ACA box snoRNAs which are associated with pseudouridylation.

SNHG1 is a host gene for a number of C/D box snoRNAs, meaning it is the gene from which these snoRNAs are transcribed. These snoRNAs are located in the introns, the non-coding regions, of the SNHG1 gene.

Clinical Significance

Alterations in the SNHG1 gene have been associated with a number of cancer types, including colorectal cancer, hepatocellular carcinoma, and breast cancer. It is thought that the SNHG1 gene may play a role in tumorigenesis and cancer progression, although the exact mechanisms are not yet fully understood.

See Also

• Small nucleolar RNA
• Long non-coding RNA
• Cancer