Sodium/bile acid cotransporter 7

Sodium/bile acid cotransporter 7 (also known as SCL10A7) is a protein that in humans is encoded by the SLC10A7 gene. It is a member of the solute carrier family of proteins, which are responsible for the transport of a variety of substances across the cell membrane.

Function

The sodium/bile acid cotransporter 7 is primarily involved in the transport of bile acids and sodium ions across the cell membrane. This process is essential for the digestion and absorption of dietary fats. The transporter uses the sodium gradient across the cell membrane to drive the uptake of bile acids, which are then used in the digestion of fats.

Structure

The SLC10A7 gene encodes a protein of 437 amino acids. The protein has a predicted molecular weight of approximately 48 kDa. It is predicted to have 10 transmembrane domains, with both the N- and C-termini located intracellularly. The protein also contains several potential phosphorylation and glycosylation sites.

Clinical significance

Mutations in the SLC10A7 gene have been associated with a rare genetic disorder known as Amelogenesis imperfecta, which is characterized by abnormal formation of the enamel or external layer of the teeth. Patients with this condition have teeth that are discolored, pitted, and prone to breakage.

See also

• Solute carrier family
• Bile acid
• Amelogenesis imperfecta

References

‎