Solid pseudopapillary neoplasm

Solid pseudopapillary neoplasm (SPN), also known as solid pseudopapillary tumor of the pancreas, is a rare type of neoplasm that primarily affects young women. It was first described by Virginia Kneeland Frantz in 1959.

Epidemiology

SPN accounts for approximately 1-2% of all exocrine pancreatic tumors. It predominantly affects young women in their 20s and 30s, with a female to male ratio of about 10:1. However, cases have been reported in patients ranging from 2 to 85 years of age.

Pathology

SPNs are typically well-circumscribed and encapsulated tumors that can range in size from 1 to 20 cm. They are composed of solid and pseudopapillary structures, hence the name. The cells of SPN are polygonal and have a low mitotic rate, which suggests a low-grade malignancy.

Clinical Presentation

Patients with SPN often present with nonspecific abdominal symptoms such as pain, discomfort, or a palpable mass. However, some patients may be asymptomatic and the tumor is discovered incidentally during imaging studies for unrelated conditions.

Diagnosis

The diagnosis of SPN is usually made based on the characteristic imaging findings on computed tomography (CT) or magnetic resonance imaging (MRI). The tumor typically appears as a well-defined, encapsulated mass with both solid and cystic components. Histopathological examination and immunohistochemistry studies are used to confirm the diagnosis.

Treatment and Prognosis

The treatment of choice for SPN is surgical resection, which can result in a cure in most cases. The prognosis for patients with SPN is generally excellent, with a 5-year survival rate of over 95%. However, recurrence can occur, especially in cases where the tumor is not completely resected.

See Also

• Pancreatic cancer
• Pancreatic neoplasms
• Exocrine pancreatic tumors