Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 3A1 (SLCO3A1) is a protein that in humans is encoded by the SLCO3A1 gene. This protein is a member of the organic anion transporter (OATP) family, which is a part of the larger solute carrier (SLC) group of proteins.

Function

The SLCO3A1 gene encodes a protein that functions as an organic anion transporter, facilitating the transport of various endogenous and exogenous substances across the cell membrane. These substances include bile acids, steroid conjugates, thyroid hormones, and eicosanoids. The protein is thought to play a crucial role in the regulation of these substances within the body.

Structure

The SLCO3A1 protein is a transmembrane protein, meaning it spans the entire width of the cell membrane. It is composed of 12 transmembrane domains, with both the N- and C-termini located on the intracellular side of the membrane. The protein also contains several potential glycosylation and phosphorylation sites, which may be involved in the regulation of its function.

Clinical significance

Mutations in the SLCO3A1 gene have been associated with various medical conditions. For example, a mutation in this gene has been linked to Rotor syndrome, a rare genetic disorder characterized by chronic, nonhemolytic unconjugated hyperbilirubinemia.

See also

• Organic anion transporter
• Solute carrier family

References

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