Sonrotoclax
Sonrotoclax[edit | edit source]
Sonrotoclax is a small molecule inhibitor that targets the B-cell lymphoma 2 (BCL-2) protein, which is involved in the regulation of apoptosis, or programmed cell death. It is being investigated for its potential use in the treatment of various types of cancer, particularly those that are resistant to conventional therapies.
Mechanism of Action[edit | edit source]
Sonrotoclax functions by binding to the BCL-2 protein, a member of the BCL-2 family of proteins that regulate cell death. BCL-2 is an anti-apoptotic protein, meaning it prevents cells from undergoing apoptosis. In many cancers, BCL-2 is overexpressed, allowing cancer cells to evade the normal cell death process and continue to proliferate. By inhibiting BCL-2, Sonrotoclax promotes apoptosis in cancer cells, thereby reducing tumor growth.
Clinical Development[edit | edit source]
Sonrotoclax is currently undergoing clinical trials to evaluate its efficacy and safety in patients with various types of cancer, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). These trials aim to determine the optimal dosing regimen and to identify any potential side effects associated with the drug.
Potential Benefits[edit | edit source]
The development of Sonrotoclax is particularly significant for patients with cancers that have developed resistance to existing treatments. By specifically targeting the BCL-2 protein, Sonrotoclax offers a novel approach to cancer therapy that could improve outcomes for patients with difficult-to-treat malignancies.
Side Effects[edit | edit source]
As with many cancer therapies, Sonrotoclax may cause side effects. Commonly reported side effects include nausea, fatigue, and neutropenia. Ongoing clinical trials are focused on further characterizing the safety profile of Sonrotoclax and managing any adverse effects that arise during treatment.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
