Soterenol
Overview of the drug Soterenol
Soterenol is a sympathomimetic drug that acts as a beta-adrenergic receptor agonist. It is primarily used for its cardiovascular effects, particularly in the management of certain types of heart failure and hypotension.
Pharmacology[edit | edit source]
Soterenol functions by stimulating beta-adrenergic receptors, which are part of the sympathetic nervous system. This stimulation leads to increased heart rate and myocardial contractility, resulting in improved cardiac output. The drug's action on beta receptors also causes vasodilation, which can help reduce vascular resistance and improve blood flow.
Mechanism of Action[edit | edit source]
Soterenol binds to beta-1 and beta-2 adrenergic receptors. Activation of beta-1 receptors in the heart increases cyclic adenosine monophosphate (cAMP) levels, which enhances calcium influx into cardiac cells, thereby increasing the force of contraction. Beta-2 receptor activation leads to smooth muscle relaxation, particularly in the bronchi and blood vessels, contributing to its vasodilatory effects.
Clinical Uses[edit | edit source]
Soterenol is used in the treatment of acute heart failure where increased cardiac output is desired. It is also employed in managing hypotension due to its ability to increase blood pressure through enhanced cardiac performance and peripheral vasodilation.
Side Effects[edit | edit source]
Common side effects of Soterenol include tachycardia, palpitations, and tremors. Due to its effects on the cardiovascular system, it may also cause arrhythmias and angina in susceptible individuals. Patients with hypertension or coronary artery disease should use Soterenol with caution.
Contraindications[edit | edit source]
Soterenol is contraindicated in patients with pheochromocytoma, a type of tumor that can exacerbate the drug's effects on blood pressure. It should also be avoided in individuals with known hypersensitivity to the drug or its components.
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