Spun glass hair
Spun Glass Hair Syndrome[edit | edit source]
Spun Glass Hair Syndrome, also known as Uncombable Hair Syndrome (UHS), is a rare genetic condition characterized by dry, frizzy hair that is impossible to comb flat. The hair often appears to stand out from the scalp and has a distinctive shiny, glass-like appearance. This condition typically becomes apparent in early childhood.
Clinical Features[edit | edit source]
Individuals with Spun Glass Hair Syndrome usually present with hair that is:
- Silvery-blond or straw-colored
- Dry and frizzy
- Standing out from the scalp
- Difficult to manage or style
The hair shaft is often triangular or heart-shaped in cross-section, which contributes to its unique texture and appearance.
Genetics[edit | edit source]
Spun Glass Hair Syndrome is primarily caused by mutations in the PADI3, TGM3, or TCHH genes. These genes are involved in the formation and structure of the hair shaft. The condition is usually inherited in an autosomal recessive manner, meaning that both copies of the gene in each cell have mutations.
Diagnosis[edit | edit source]
Diagnosis of Spun Glass Hair Syndrome is typically based on:
- Clinical examination of the hair
- Microscopic analysis of the hair shaft
- Genetic testing to identify mutations in the associated genes
Management[edit | edit source]
There is no specific treatment for Spun Glass Hair Syndrome, but management focuses on:
- Gentle hair care practices
- Use of moisturizing shampoos and conditioners
- Avoidance of harsh chemical treatments
In some cases, the hair texture may improve with age.
Prognosis[edit | edit source]
The condition is benign and does not affect overall health. Hair texture may improve over time, particularly after puberty.
Related Conditions[edit | edit source]
Spun Glass Hair Syndrome is related to other hair shaft disorders, such as:
Research[edit | edit source]
Ongoing research is focused on understanding the genetic basis of Spun Glass Hair Syndrome and developing potential therapies to manage the condition.
External Resources[edit | edit source]
NIH genetic and rare disease info[edit source]
Spun glass hair is a rare disease.
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Contributors: Prab R. Tumpati, MD
