Squalamine lactate

Squalamine lactate is a steroidal compound derived from the dogfish shark (Squalus acanthias). It is a natural product that has been studied for its potential use in the treatment of various diseases, including cancer, bacterial infections, and viral infections.

History

Squalamine lactate was first isolated in 1993 by Michael Zasloff, a researcher at the Georgetown University Medical Center. Zasloff discovered the compound while studying the immune system of the dogfish shark, a species known for its remarkable resistance to infections.

Structure and Properties

Squalamine lactate is a polyamine compound, meaning it contains multiple amine groups. It is a water-soluble, amphipathic molecule, which allows it to interact with both water and fat-soluble substances. This property is believed to contribute to its potential therapeutic effects.

Therapeutic Potential

Squalamine lactate has been studied for its potential use in a variety of medical applications. Its most notable potential use is in the treatment of cancer. Laboratory studies have shown that it can inhibit the growth of tumor cells and induce apoptosis, or programmed cell death.

In addition to its potential anti-cancer effects, squalamine lactate has also been studied for its potential to treat bacterial and viral infections. It has been shown to have antimicrobial properties, and some research suggests it may be effective against certain types of viruses, including dengue virus and Zika virus.

Clinical Trials

Several clinical trials have been conducted to evaluate the safety and efficacy of squalamine lactate in humans. These trials have primarily focused on its potential use in the treatment of cancer, particularly ovarian cancer and lung cancer. While some results have been promising, further research is needed to fully understand the potential benefits and risks of this compound.

See Also

• Shark cartilage
• Antimicrobial properties of shark skin
• Natural product drug discovery