Src (gene)

Src is a proto-oncogene that encodes a non-receptor tyrosine kinase involved in the regulation of various cellular processes, including cell growth, differentiation, survival, and migration. Src is a member of the Src family kinases (SFKs), which are important in the signaling pathways of many cellular functions.

Function

Src plays a critical role in the signal transduction pathways that control the cytoskeleton, cell adhesion, and cell cycle progression. It is activated by various growth factors, cytokines, and integrins. Upon activation, Src phosphorylates specific tyrosine residues on target proteins, leading to the modulation of their activity.

Clinical Significance

Deregulation of Src activity has been implicated in the development and progression of several types of cancer, including breast cancer, colon cancer, and lung cancer. Src is often overexpressed or hyperactivated in these cancers, contributing to increased tumor growth, angiogenesis, and metastasis.

Inhibition

Due to its role in cancer, Src is a target for anticancer therapy. Several Src inhibitors, such as dasatinib and bosutinib, have been developed and are used in the treatment of certain cancers. These inhibitors work by blocking the kinase activity of Src, thereby reducing cancer cell proliferation and survival.

Research

Ongoing research is focused on understanding the precise mechanisms by which Src contributes to cancer and other diseases. Studies are also exploring the potential of Src inhibitors in combination with other therapies to enhance their efficacy and overcome resistance.

See Also

• Tyrosine kinase
• Oncogene
• Signal transduction

External Links

• SRC gene - NCBI
• UniProt entry for SRC