Stem cell factor receptor
Stem cell factor receptor (also known as SCFR) is a protein that in humans is encoded by the KIT gene. It is a type of tyrosine-protein kinase that is involved in various cellular processes such as cell survival, proliferation, and differentiation.
Function[edit | edit source]
The SCFR protein is a receptor for stem cell factor (SCF), also known as c-kit ligand. This receptor-SCF interaction plays a crucial role in the development and function of several cell types, including hematopoietic cells, melanocytes, and germ cells.
Clinical significance[edit | edit source]
Mutations in the KIT gene are associated with several diseases, including gastrointestinal stromal tumors, mastocytosis, acute myeloid leukemia, and piebaldism. In addition, the SCFR protein is a target for certain types of cancer therapy.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- KIT gene at NCBI
- SCFR protein at UniProt
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Contributors: Prab R. Tumpati, MD
