Stem cell factor receptor

Stem cell factor receptor (also known as SCFR) is a protein that in humans is encoded by the KIT gene. It is a type of tyrosine-protein kinase that is involved in various cellular processes such as cell survival, proliferation, and differentiation.

Function

The SCFR protein is a receptor for stem cell factor (SCF), also known as c-kit ligand. This receptor-SCF interaction plays a crucial role in the development and function of several cell types, including hematopoietic cells, melanocytes, and germ cells.

Clinical significance

Mutations in the KIT gene are associated with several diseases, including gastrointestinal stromal tumors, mastocytosis, acute myeloid leukemia, and piebaldism. In addition, the SCFR protein is a target for certain types of cancer therapy.

See also

• Tyrosine kinase inhibitor
• Stem cell factor

External links

• KIT gene at NCBI
• SCFR protein at UniProt

Stem cell factor receptor Resources
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