Stopping rule

A procedure that allows interim analyses in clinical trials at predefined times, whilst preserving the Type I error at some pre-specified level.

In some trials, a statistical criterion that, when met by the accumulating data, indicates that the trial can or should be stopped early to avoid putting participants at risk unnecessarily or because the intervention effect is so great that further data collection is unnecessary. Usually defined in the trial protocol and implemented during a planned interim analysis.

Stopping rule Resources
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