Subependymal zone

Subependymal Zone

The Subependymal Zone (SEZ), also known as the Subventricular Zone (SVZ), is a region in the brain where neurogenesis (the process of generating functional neurons from neural stem cells) occurs. It is one of the few areas in the adult mammalian brain where neurogenesis is known to occur.

Anatomy

The Subependymal Zone is located along the walls of the lateral ventricles, a set of four interconnected cavities in the brain where cerebrospinal fluid is produced. The SEZ is composed of four layers: the ependymal layer, the hypocellular gap, the astrocytic ribbon, and the transitional zone.

Function

The primary function of the Subependymal Zone is the production of new neurons, a process known as neurogenesis. The SEZ is one of the few areas in the adult mammalian brain where neurogenesis is known to occur. The new neurons produced in the SEZ migrate to other areas of the brain, such as the olfactory bulb, where they integrate into existing neural circuits.

Clinical Significance

The Subependymal Zone has been implicated in a number of neurological disorders, including Parkinson's disease, Alzheimer's disease, and stroke. Research has suggested that enhancing neurogenesis in the SEZ could potentially be used as a therapeutic strategy for these disorders.

Research

Research into the Subependymal Zone is ongoing, with scientists seeking to better understand the mechanisms of neurogenesis and how they can be manipulated for therapeutic purposes. This research could potentially lead to new treatments for a variety of neurological disorders.

See Also

• Neurogenesis
• Lateral ventricles
• Parkinson's disease
• Alzheimer's disease
• Stroke