Sulbenicillin
A detailed overview of the antibiotic sulbenicillin
Sulbenicillin[edit | edit source]
Sulbenicillin is a beta-lactam antibiotic belonging to the penicillin class. It is a semi-synthetic derivative of ampicillin and is used primarily for its broad-spectrum antibacterial activity. Sulbenicillin is particularly effective against Gram-negative bacteria, making it a valuable agent in the treatment of infections caused by these organisms.
Chemical Properties[edit | edit source]
Sulbenicillin is characterized by its unique chemical structure, which includes a beta-lactam ring essential for its antibacterial activity. The presence of a sulfonic acid group in its structure enhances its solubility and stability compared to other penicillins. This modification allows sulbenicillin to be administered in higher doses, increasing its efficacy against resistant bacterial strains.
Mechanism of Action[edit | edit source]
Sulbenicillin, like other beta-lactam antibiotics, exerts its effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, disrupting the cross-linking of peptidoglycan chains. This leads to cell lysis and ultimately, the death of the bacterium.
Clinical Uses[edit | edit source]
Sulbenicillin is used in the treatment of various infections, particularly those caused by Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. It is often employed in the management of urinary tract infections, respiratory tract infections, and sepsis.
Administration and Dosage[edit | edit source]
Sulbenicillin is typically administered via intravenous or intramuscular injection. The dosage and duration of treatment depend on the severity of the infection and the patient's overall health status. It is important to adjust the dosage in patients with renal impairment to prevent toxicity.
Side Effects[edit | edit source]
Common side effects of sulbenicillin include allergic reactions, such as rash, itching, and anaphylaxis. Gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, may also occur. As with other antibiotics, prolonged use can lead to the development of antibiotic resistance.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
