Survivin

Survivin is a protein that has been identified as an inhibitor of apoptosis (programmed cell death). Its gene is the BIRC5 gene, which is located on the human chromosome 17. Survivin is a member of the inhibitor of apoptosis (IAP) family, playing a critical role in the control of cell division and the inhibition of apoptosis. This dual function makes survivin a key player in cancer development and progression, as it helps cancer cells to evade programmed cell death and promotes tumor growth.

Function

Survivin is involved in the regulation of mitosis and has been shown to inhibit apoptosis by interfering with the activity of caspases, which are enzymes that play a crucial role in the execution of cell death. During the cell cycle, survivin is expressed in the G2/M phase, where it associates with the mitotic spindle and is involved in the regulation of mitosis. Its expression is tightly regulated, and its dysregulation can lead to uncontrolled cell proliferation and cancer.

Clinical Significance

Due to its role in inhibiting apoptosis and promoting cell proliferation, survivin is considered a key factor in cancer biology. It is overexpressed in most human tumors, including lung, breast, colon, and pancreatic cancers, making it a potential target for cancer therapy. The overexpression of survivin in cancer cells is associated with increased tumor aggressiveness, poor prognosis, and resistance to chemotherapy and radiation therapy.

Researchers are exploring various strategies to target survivin in cancer therapy, including the use of small molecule inhibitors, antisense oligonucleotides, and immunotherapy. These approaches aim to reduce survivin levels in cancer cells, thereby promoting apoptosis and inhibiting tumor growth.

Survivin and Chemoresistance

One of the challenges in cancer treatment is the development of resistance to chemotherapy. Survivin has been implicated in the development of chemoresistance, as its overexpression can protect cancer cells from the cytotoxic effects of chemotherapy drugs. Targeting survivin in combination with chemotherapy may enhance the efficacy of cancer treatment by overcoming resistance mechanisms.

Future Directions

The ongoing research on survivin is focused on understanding its complex role in cancer biology and exploiting this knowledge for the development of novel cancer therapies. Targeting survivin, along with other key molecules involved in apoptosis and cell proliferation, holds promise for improving cancer treatment outcomes.

See Also

• Apoptosis
• Cancer
• Chemotherapy
• Inhibitor of apoptosis
• Mitosis

References

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