Synaptotagmin-14
Synaptotagmin-14 (SYT14) is a protein that in humans is encoded by the SYT14 gene. It is a member of the synaptotagmin family, which are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse.
Function[edit | edit source]
Synaptotagmin-14, like other synaptotagmins, has a high affinity for calcium. It is thought to act as a calcium sensor, interacting with SNARE proteins to trigger vesicle fusion and neurotransmitter release. However, the exact role of synaptotagmin-14 in this process is not fully understood and is the subject of ongoing research.
Clinical significance[edit | edit source]
Mutations in the SYT14 gene have been associated with a form of spinocerebellar ataxia, a neurodegenerative disorder characterized by poor coordination and balance. Further research is needed to understand the exact role of synaptotagmin-14 in this disease.
See also[edit | edit source]
References[edit | edit source]
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