Syndecan 1

Syndecan 1 is a protein that in humans is encoded by the SDC1 gene. It is a member of the syndecan family, a group of transmembrane proteoglycans that are involved in the binding of cells to the extracellular matrix, the intercellular structure that supports cells in tissues.

Structure

Syndecan 1 is a type I transmembrane protein, meaning it spans the cell membrane with its C-terminal end inside the cell and its N-terminal end outside the cell. The extracellular portion of the protein is modified with heparan sulfate and chondroitin sulfate chains, which are involved in binding to other molecules in the extracellular matrix.

Function

Syndecan 1 plays a crucial role in cell adhesion, cell migration, and cell signaling. It interacts with various extracellular matrix proteins, growth factors, and other cell surface molecules, thereby influencing cell behavior. In addition, Syndecan 1 is involved in the regulation of cytoskeleton organization and cell shape.

Clinical significance

Alterations in the expression of Syndecan 1 have been associated with various diseases, including cancer. In particular, decreased expression of Syndecan 1 has been observed in several types of cancer, suggesting a potential role in tumor progression. Moreover, Syndecan 1 has been proposed as a potential biomarker for certain cancers.

See also

• Syndecan
• Proteoglycan
• Extracellular matrix
• Cell adhesion
• Cell migration