TAS2R43

TAS2R43 is a protein that in humans is encoded by the TAS2R43 gene. It is a member of the bitter taste receptor family, which is a group of G protein-coupled receptors. This family is specifically known for their role in the detection of bitter compounds, and are thus of particular interest in the study of taste and flavor.

Function

The TAS2R43 protein is a taste receptor that functions in the perception of bitter taste. It is found in the taste buds of the tongue and is activated by a variety of bitter compounds. The activation of TAS2R43 and other bitter taste receptors triggers a signal transduction pathway that ultimately leads to the perception of bitterness.

Genetics

The TAS2R43 gene is located on chromosome 12 in humans. It is one of about 25 similar genes that encode bitter taste receptors. Variations in these genes can lead to differences in individuals' perception of bitterness. For example, some people may find certain foods more bitter than others due to differences in their TAS2R43 gene.

Clinical significance

Research has suggested that TAS2R43 and other bitter taste receptors may have roles beyond taste perception. For instance, these receptors have been found in other parts of the body, such as the lungs and the gastrointestinal tract. This has led to speculation that they may be involved in other physiological processes, such as the regulation of appetite or the detection of toxins.

See also

• Taste receptor
• G protein-coupled receptor
• Bitter taste