TAS2R50

TAS2R50 is a gene that encodes a member of the taste receptor family of proteins. These proteins are involved in the perception of bitter taste, and are predominantly expressed in the taste buds of the tongue and palate.

Function

The TAS2R50 gene is part of the TAS2R gene family, which is responsible for the detection of bitter compounds. The proteins encoded by these genes are G protein-coupled receptors that are activated by a variety of bitter-tasting compounds. Upon activation, these receptors trigger a signaling cascade that results in the perception of bitterness.

Structure

The TAS2R50 protein is a seven-transmembrane domain receptor, a common structure for G protein-coupled receptors. The protein is approximately 300 amino acids in length, and its structure allows it to bind to a variety of bitter compounds.

Clinical significance

Variations in the TAS2R50 gene have been associated with differences in taste perception, particularly the perception of bitterness. These variations can influence dietary choices and may have implications for health and nutrition. For example, individuals with certain TAS2R50 variants may be more sensitive to the bitterness of certain foods and therefore less likely to consume them.

File:TAS2R50 gene location.png

Location of the TAS2R50 gene on chromosome 12.

See also

• Taste receptor
• G protein-coupled receptor
• TAS2R gene family

References

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