TCF21
TCF21 (Transcription Factor 21) is a protein that in humans is encoded by the TCF21 gene. It is a member of the basic helix-loop-helix (bHLH) family of transcription factors, which play a significant role in cell differentiation and development.
Function[edit | edit source]
TCF21 is a transcription factor of the bHLH family. It is known to play a crucial role in the differentiation of various cell types, including epithelial cells, mesenchymal cells, and cardiac cells. The protein is also involved in the development of the heart and lungs.
Clinical significance[edit | edit source]
Mutations in the TCF21 gene have been associated with a variety of diseases, including coronary artery disease and several types of cancer. In particular, TCF21 has been implicated in the development of lung cancer, breast cancer, and ovarian cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- TCF21 at the National Center for Biotechnology Information
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Contributors: Prab R. Tumpati, MD
