THDOC
THDOC (Tetrahydrodeoxycorticosterone) is a neurosteroid that is produced in the adrenal gland and the brain. It is a potent GABAergic agent with anxiolytic and anticonvulsant properties.
Production[edit | edit source]
THDOC is synthesized from progesterone in a two-step process that involves the enzymes 5α-reductase and 3α-hydroxysteroid dehydrogenase. The production of THDOC is increased in response to stress and it plays a role in the body's response to stress.
Mechanism of action[edit | edit source]
THDOC acts as a positive allosteric modulator of the GABAA receptor, enhancing the effects of the neurotransmitter GABA. This results in an increase in inhibitory neurotransmission, which can have a calming effect and reduce the activity of the central nervous system.
Clinical significance[edit | edit source]
Due to its anxiolytic and anticonvulsant properties, THDOC has potential therapeutic applications in the treatment of conditions such as anxiety disorders and epilepsy. However, further research is needed to fully understand the potential benefits and risks of THDOC as a therapeutic agent.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
