TIA1

TIA1 is a protein that in humans is encoded by the TIA1 cytotoxic granule-associated RNA binding protein gene. It is involved in apoptosis and stress granule formation, playing a crucial role in the regulation of gene expression.

Function

The TIA1 gene encodes a protein that is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in Jurkat T lymphocytes. The protein includes three RNA recognition motif (RRM) domains.

Clinical significance

Mutations in the TIA1 gene have been associated with a form of familial amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the death of motor neurons in the brain and spinal cord.

Research

Research into the TIA1 gene and its associated protein may provide insights into the mechanisms of apoptosis and cell destruction, potentially leading to therapeutic advances in diseases such as ALS.

See also

• RNA-binding protein
• Apoptosis
• Amyotrophic lateral sclerosis