TPSB2

TPSB2 or Tryptase Beta 2 is a protein that in humans is encoded by the TPSB2 gene. It is a member of the serine protease family. TPSB2 is predominantly expressed in mast cells, where it is packaged in secretory granules and released in response to various stimuli.

Function

TPSB2 is a trypsin-like serine protease, which is found in secretory granules of mast cells and plays a significant role in inflammation and allergy responses. It is involved in the cleavage of protease-activated receptor 2, a protein involved in a variety of cellular responses. TPSB2 is also implicated in the activation of G protein-coupled receptors, which are involved in various physiological processes.

Clinical Significance

Alterations in the TPSB2 gene have been associated with various diseases. Elevated levels of TPSB2 have been found in patients with asthma, rhinitis, and atopic dermatitis, suggesting a role in the pathogenesis of these conditions. Moreover, TPSB2 has been implicated in the progression of pulmonary fibrosis and chronic obstructive pulmonary disease (COPD).

Research

Research is ongoing to understand the precise role of TPSB2 in disease processes and to explore its potential as a therapeutic target. Studies are also being conducted to develop inhibitors of TPSB2, which could potentially be used in the treatment of conditions such as asthma and COPD.

See Also

• Serine protease
• Mast cell
• Asthma
• Chronic obstructive pulmonary disease