TRAIL-R2

TRAIL-R2 (also known as TNF-related apoptosis-inducing ligand receptor 2) is a protein that in humans is encoded by the TRAILR2 gene. It is a member of the tumor necrosis factor receptor superfamily, and is one of the receptors for the TRAIL (tumor necrosis factor-related apoptosis-inducing ligand).

Function

The protein encoded by this gene is a death domain containing receptor for TRAIL. The receptor is activated by TRAIL binding, and it transmits an apoptosis signal. Studies with FADD, a signal adaptor protein, suggest that the apoptotic signal induced by this receptor is mediated by FADD's death effector domain. This gene overlaps in a tail-to-tail manner with the gene encoding MAP3K14/NIK, a kinase involved in NF-kappaB activation, on chromosome 8. The two genes are transcribed in opposite directions; this gene's promoter was found to be a bidirectional promoter shared with the neighboring gene.

Clinical significance

Mutations in this gene have been associated with various diseases, including cancer. TRAIL-R2 has been found to be overexpressed in many tumor cells, and it has been suggested that this overexpression may be a mechanism by which tumors evade the immune system.

See also

• TRAIL
• Tumor necrosis factor receptor

External links

• TRAILR2 at the National Center for Biotechnology Information

TRAIL-R2 Resources
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